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Topic Title: Proteostasis- Protein pathways in Diabetes
Created On: 02/23/2010 10:22 AM
 
 02/23/2010 10:22 AM

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19556

[p]A fascinating new field relevant to T2D is emerging, beyond genetics and beyond even proteomics (how proteins are formed). It is called proteostasis: the study of how proteins pass through certain cellular pathways in the body in order to become fully functional, stable, and correctly positioned. These pathways can both degrade with age and/or deteriorate from the cumulative effect of high blood sugar. It is speculated that continued high blood sugar leads to insulin resistance and thence, T2 diabetes. [/p][p]Recently, a lot of money has started to pour into this field. One start-up spun out of Scripps in San Diego, Proteostasis Therapeutics received $45M in one [url=http://www.xconomy.com/boston/2010/02/18/proteostasis-a-rich-boston-biotech-with-san-diego-ties-grows-to-pursue-diseases-of-aging/?single_page=true]round of financing[/url]! Fascinating to see how this field will develop.[/p]

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