Blog Entries With Tag: Metformin


Posted: Apr 14, 2013
I had my birthday last week, and the way I celebrated it was to attend a JDRF Symposium a few hours drive away from my home here in Quebec in the province next door, Ontario.
 
What a blast – being with others that are wishing  to find a CURE* for T1D's (Type 1 Diabetics). What I found the most interesting, that at this symposium they were discussing research aimed at older T1D’s  –  not just the younger ones which has always seemed to be the research topic discussions in the past at the symposiums I have attended over the years.  They are looking ahead – at those of us who were young T1D’s at some point in our life (I was diagnosed in the 60’s) – and living our lives to the fullest with all the new research and innovations – while we wait for that CURE.

Doctor Irene Hramiak from the University of Western Ontario (UWO) was the research doctor that night who presented her role in a  project called REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL).  The aim is to test whether 3 years treatment with metformin added to insulin therapy to reduce thickening of the arteries and prevent cardiovascular disease in T1 diabetics.  Heart disease is one of the many problems that diabetics can develop over the years due to the ups and downs of our blood sugar and diabetes control – not all of us can attain a purrfect  4.5-6% A1C that a non-diabetic has.

The study will be monitoring the thickness of the arteries in the neck, which is a marker used to predict the risk of future heart attacks and strokes (and yes, while she was talking about this, I was touching my fingers around my neck).  Also, the study will test the drug’s effects on the control of diabetes and treatment.  One of the small drawbacks of the recepient being on the actual Metformin maybe stomach discomfort and/or diarrhea (which one of my Ottawa friends who is going on this project says might help them lose weight as well as get better control of their A1C).

For those that do partake, of course they'll either be on the drug or they won't, and will be clossely monitored to ensure that they stay in good control (that would be my greatest concern as a test guinea pig).  The criteria fo taking part in this tudy is that you have to be over 40 years of age, had diabetes for more than 5 years or more, with an A1C above 7% but under 10%.  There is other criteria in order to take part in this trial which you can find at this link.  Note that this trial is being conducted in the UK, Australia, Denmark, and the Netherlands and they maybe recruiting as we speak (for Canadians - the deadline is rapidly approaching for participants as they hope to start in the next few months). 

Art made of syringes by Dana Heffern
*
When I posted about attending this symposium last week on Facebook a few long time T1D's like myself got their feathers a wee bit ruffled (very attractive to a bird loving cat like myself I might add). They were disillusioned by JDRF's  promise of “a cure will be found in 5 years”.  That is perhaps an old statement they used many moons ago but so far over the years I've attended JDRF symposiums there are no longer make promises made like that.  JDRF's goal all along has been to, and I quote - " improve the lifes of every person affected by T1D by accelerating progress on the most promising opportunities for curing, better treating, and preventing the disease.
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Posted: Oct 29, 2009

Well, I'm finally getting my life back to order.  Don't think Mike, my husband appreciated my being away at the IDF Diabetes World Congress for 5 days (I averaged 12 hour days there), as my Domestic Engineering duties sort of went the way of the dodo bird.  I am back on track, almost, just don't pay me a surprise visit right now, as it still looks like a bomb went off in my house (I need a housekeeper as one of my friends says - treat yourself).

So, below you will find a rather amusing picture of me.  It was a way to let off some steam I think for all the delegates that were there, as attending seminars, learning new ideas of coping with diabetes can sometimes make for a tired brain.  It was fun seeing people from all over the world, putting on the RCMP uniform and standing with the Canadian Rockies behind them!  Of course, I had to do something different didn't I? Being the animal lover, I had to go and pet the moose.  He was very bristly, incase you are wondering! The staff had no problem the next day remembering my picture, no number required - just had to tell them - "I'm the moose lover!"

Novo Nordisk FatCatAnna

I went to the Novo Nordisk booth because I was interested in learning about Victoza, which Type 2 diabetics can inject once a day.  They can either use it alone, or combine it with their Metformin or sulphonylurea treatment.  The big thing with this insulin that they are thumping their chests about is that it helps patients gain better blood glucose control WITHOUT the weight gain, which often happens when going on insulin therapy.  According to one of the documents I have on hand, visceral fat (this is fat that surrounds our internal organs) was reduced by 13% to 16% in patients treated with Victoza + Metformin.  I know for a few diabetics diagnosed with Type 2, weight can be an issue, and of course, the sooner we shed it, eat sensible and exercise, the better our diabetes is controlled!

So in a nutshell it'll be able to do the following -

  • Reductions in A1C of up to 2.74%
  • Reductions in weight by up to 2.8 kg
  • Reduction in blood pressure readings
  • Improvement is beta-cell function (makes me wonder with time, if you start early enough - you might reverse diabetes as your pancreas start to produce insulin).

Not sure when it will be coming to the market in North America as all the information I am finding  is based in Europe - therefore I'm unable to post the Novo Nordisk link for you to check it out for yourself unless you register there yourself.  I've done abit of research on Victoza and there seems to be some problems with bringing it to the market due to labeling of the product believe it or not in the United States!  We'll just have to wait and see and be patient with FDA, but the forecast is for sometime in 2010. 

Also, if there are any of my friends from abroad reading my scribbles, and you've got some insight into Victoza, please feel free to share with us!

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