What does anybody know about the use of nasal (spray) insulin?
By: 19556: Nov, 07, 2009 18:16 PM
So on this there are pluses & minuses IMHO -
On the plus side- fast, less painful, more convenient, less socially awkward?
On the minus side- mostly unanswered questions- how will affect the mucosa long-term? & what are the potential effects on the brain given that the nasal nerves have direct brain connections (one reason nasal delivery is being heavily studied/tested for neurological drugs which have to cross the "blood-brain-barrier"
By: FatCatAnna: Nov, 03, 2009 16:29 PM
Hmm, nasal insulin, like you say, nose is plugged up, how much of the spray will actually enter into the walls of the nostrils, and not be expelled later?
The theory that I had read about the nasal insulin, besides it not involving taking needles, is that it is supposed to help treat neuropathy, something that many diabetics who aren't managed well develop (touch wood, I haven't been touched yet). According to what I read, it's estimated that only 2% of injected insulin goes into the brain/nerves, but when insulin is "sniffed" that about 98% of the insulin goes directly to the brain. By doing that, the insulin travels along the nerves of the spinal cord to the peripheral nerves and slows down the degeneration.
I never thought that really when you look at it, insulin is good for the nerves not just in lowering our BG's! It's like starving your nerves of the nutrients it needs to stay healthy and vital! Eureka!!!
Right now there's a study taking place in Calgary, Alberta - with 40 Type 1 diabetics. You can read more about this at this link.
Also, what about "inhaled insulin" aka Exubera? That was supposed to be the cats meow when it was first brought to the market in 2006. It was discontinued by the manufacturer, Pfizer a year later due The sad thing is, that it didn't survive on the market due to patients and physicians not being interested in it. Because of this Pfizer decided not to sink anymore investment into it - sad to say. Perhaps it would have worked - who knows?
The link that follows (by John Walsh) explains it abit better then I can - http://www.diabetesnet.com/diabetes_treatments/insulin_inhaled.php
By: spark: Nov, 03, 2009 13:15 PM
judging by the tags for this blog entry, i see you fell for that text box too.. I definitely thought that that was where I was supposed to comment too.. hehe oh wells.
as for your question however, that's a good point.. how does one ensure an accurate dose if the nose is blocked? Hm.. What about nasal sprays that exist now? I mean, I don't know the science behind it all, but i'm sure there's supposed to be an accurate dose for those as well, right? I'm sure there's a much stricter dosage guideline thing that you have to follow with insulin compared to cold medicine, but still.. same principle, no?
If not, there's always the option of using some sort of pressurized system that guarantees that the insulin gets far enough up into your nasal cavity, regardless of how blocked your nose gets.. though it sounds somewhat painful and unpleasant to have something just shoot up through your nose...
or MAYYYBEE, they can decide that instead of having a nasal spray, they can have something like an inhaler? I mean, i know that asthmatics use inhalers to take in the medication because their condition is related to their lungs and such.. but would it be too much of a stretch to try and create an inhaler for diabetics too? that would definitely help solve the whole stuffy-nose issue.. not so sure if it's possible though.. just a thought.
By: : Nov, 03, 2009 11:32 AM
This is breakthrough research as far as delivery is concerned. Question: what about if a kid has a stuffed up nose. Could you guarantee an accurate does and/or could you still deliver it? It still is thinking outside the box" and that is good.
By: spark: Oct, 29, 2009 10:58 AM
Don't really know much about it, but i did find an article online which talks about a Japanese company that has begun developing a nasal insulin spray..
Here's an excerpt:
"Toray Industries, working in conjunction with Hoshi University in
Tokyo, reported that it has developed a compound that, mixed with a
peptide, successfully delivered insulin into animals' bloodstreams in a
test. (Peptides are natural or synthetic molecules that contain two or
more amino acids.)"
If you want to read the actual article, here's the link: http://www.diabeteshealth.com/read/2009/08/28/6337/japanese-companys-stock-jumps-10-percent-on-news-of-insulin-nasal-spray/
If this actually goes into production and then become available worldwide, can you imagine how much simpler life would be for diabetics? especially kids? hmmm.. just a thought.. :)
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