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Cells That “Think” They’re Not Consuming Glucose May Hold a Key to Longer Lifespan

Doris' Blog
By: dorisjdickson

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Posted: Apr 7, 2009 9:16
  • 1 Comment.
  • Cells That “Think” They’re Not Consuming Glucose May Hold a Key to Longer Lifespan

    The following article was posted in the April 6th online edition of Diabetes Health.  Following the article is the "comment" I posted.  Not everyone will appreciate my response ... but keep in mind I said "we."

    "Apr 1, 2009

    Canadian scientists studying the effects of glucose on cellular aging have discovered an unusual effect that could change how doctors treat diabetes and even address the human lifespan. 

    It appears that if a cell on a glucose-rich diet does not  "think" it is consuming glucose, it lives longer than cells on a reduced-glucose diet. The key to this finding by researchers at the University of Montreal is the presence of a genetically created sensor in the cell that tells it that it is receiving glucose. If the sensor is removed, the cell proceeds as though there is no glucose available for it to metabolize. In other words, the presence of glucose is almost immaterial if the cell does not act as though glucose is present.

    The finding came from a study on aging that was looking to see how glucose-reduced diets affect cellular lifespan. Scientists have long known that severely restricted caloric intake can increase the lifespan of laboratory mice by as much as 40 percent. Because glucose intake is drastically reduced when subjects consume perhaps only 50 percent of their caloric intake, the scientists asked whether the reduction in glucose alone could account for the increase in lifespan. Their question was based on the observation that even if the amount of glucose a cell metabolizes is reduced, the byproducts of metabolization are still thought to be major factors in the aging process. 

    Using yeast cells, which are much like human cells in many respects, the Canadian researchers asked what would happen if they removed the ability of cells to detect glucose by taking away their built-in glucose sensors. The result was that such sensor-deprived cells lived longer than their low-glucose-diet counterparts.

    Indirectly, the scientists' findings confirm that the over-consumption of sugar can decrease lifespan because of the toxic byproducts its metabolization produces. On the other hand, if scientists can eventually manipulate cells to "think" that they are not receiving sugar, it could help people with such metabolic disorders as diabetes overcome the effects of chronically high glucose levels."

    My Comment:

    In my eyes, that is further proof that Dr. Bernstein continues to be right in recommending lower carb intake. That is ... that the ADA recommended feed thy face carbs as long as you feed thy cells insulin is wrong and unhealthy. Good luck convincing diabetics though ... frequently when I ask other diabetics if they choose the watermelon or their kidneys, they say the watermelon!

    I can only be amused by the fact that, like the patients, the researchers prefer to try to shut off the bodies' normal response to high glucose levels rather than LISTEN to the body. We (and I mean we) continue to be a group in need of immediate self-gratification it seems.

    Doris J. Dickson


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  • By: FatCatAnna: Apr, 07, 2009 13:35 PM

    You beat me to it - I was going to post this in the forums a few days ago <lol>.  I have to admit - I'm not aware about the ADA force feeding the carbs bit on diabetics - but you "talk" alot about it.  From discussions I've had with other diabetics - all types - we all handle our diets in ways that works for us.  I'm in the middle I guess - with balancing carbs/proteins to help keep my BG's in a range ... I'm happy with that right now - who knows I may change over time.. again <lol>.  Like you say above "LISTEN to the body"!


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