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Generex - drug delivery via the inner lining of the mouth

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By: FatCatAnna

The Roller Coaster Ride of Diabetes! Whoo! Whoo!

I am a Type 1 diabetic diagnosed back in the early 60's as a child.  I am living in Montreal, Canada and enjoy scribbling about diabetes from time to time. I’ve had my ups / downs just like any person would experience with going through life - diabetic or not.  My motto in life?  Diabetes does not control me – I control it!! 

You can find more posts/discussions at my Facebook page called "The Roller Coaster Ride of Diabetes" and also on Twitter under the name of FatCatAnna.  Feel free to follow me at both places or send me a private message!

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 Blog Entries
The joys of having Bowie my CGMS – Chapter 1 - Sep 02
 Okay, for those of you who have never read my #dblogs before, I give names to all my little gizmos that I use for controlling my diabetes.  What we have today, ...
In a slump and scared - Jul 21
It’s rare for me to compose a #dblog that is not all “chirpy chirpy” … I think the last time I did one that was kind of down was at Diabetes1.org ...
Surviving the Holocaust with Type 1 diabetes - Mar 27
  " To the best of my knowledge, I am the only diabetic who survived years of imprisonment in German concentration camps. This is my story "   The above words ...
Sugar and Your Health - Mar 06
The other day I emptied out a 4 kg (about 10 lbs) of white sugar that I had dated a year ago when I opened it.  I use white sugar purely for cooking (I make my own ...
Eating from the ground - Yuca Fries - Feb 20
I am home now from a working holiday, in the Bahamas and Miami.  Despite the weather being abit cooler then normal (they only get 2 weeks of winter - we were there in ...
Posted: Nov 21, 2009 21:06
  • Generex - drug delivery via the inner lining of the mouth

    When I was attending the IDF World Diabetes Congress last month, I came across a few products from a company based in the States, called Generex.  They are involved in research and development of drug delivery systems, but not through the usual ways that we know of.  Basically instead of by injection, they are developing drugs that are taken via the lining of the inner mouth (RapidMist™ device). Not only will their products be used for diabetes, but also for pain management and cancers.

    Generex Oraly-LynOne of their major products they are introducing to the market is an oral insulin (Generex Oral-lyn™).  This is used for both Type 1 and 2 diabetics and is currently sold in Ecuador.  It was also approved for sale in Indian back in 2007, and currently is in various stages of clinical development around the world.  Right now, Phase III clinical trials of their oral insulin has startied in North America, Russia, Romania, Bulgaria, Poland and the Ukraine.

    Can you imagine, not having to inject anymore?  I would be very interested in seeing more information on their product as it comes out.  So, if I do come across anything to share with you all, hopefully you'll be as interested as I am.

    GlucoserapidsprayThe other product that I came across and managed to get a few samples of (with the Oral-lyn™ I managed to get a squeezy stress toy ) - is Glucose RapidSpray™.  You may have seen this in the American market already, but it is new to us here in Canada.  This product can be used to treat a low blood sugar, and claims not to cause a rapid spike in the blood sugars, like some other products do (I tend to find I spike up, due to taking too much sugar).  I tested it out finally last night, when waking up around 04h30 with a blood sugar reading of 2.9 mmol/l (52 mg/dl).  I followed the simple instructions, and sprayed 10 times inside of my cheek, retested my blood sugar in about 10 minutes (3.1 mmol/l - 55 mg/dl) - sprayed 10 times more (I had strawberry flavour - yum) - and trotted off to bed at that point.  When I woke up in the morning, my blood sugar, was at 4.0 mmol/l (72 mg/dl) - and I have to admit, I was pretty pleased with the results!

    To find out more about other products that Generex has (e.g. BaBoom!™ and Crave-NX) - check out their website at this link.





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  • By: : Jan, 26, 2010 15:46 PM


    I was not part of any trial, in fact I'm Type 2. Some friends from India brought me a two-pack and I tested it out. It was more experimental since I had limited supply. I basically used 2-3 puffs when my BG was too high and it brought it down rather quickly.

    There is a protocol to use it for post-prandial spikes but that requires a lot more puffs, which I didn't want to use.

    But, overall, I found it incredibly convenient and effective for lowering BG quickly. Here's a few comments from a Generex Forum Type 1 user:

    Wow, it works although you would need quite a few sprays if you planned to eat loads of carb for one meal or if if your blood sugar level was a bit elevated. For myself I have found that 1 spray is all I need to handle 20 grams of carb on a lowish blood sugar level.

    Oral-lyn's action is very fast and I have found that its duration is virtually over within 3 hours. I don't need to snack at all which is great really. On u100 rapid acting insulin I would need about 4 units to handle 20 grams of carb whereas with Oral-lyn it's only 1 or 2 sprays depending on what my blood sugar levels are.

    By: FatCatAnna: Jan, 26, 2010 14:21 PM

    LarryD - just curious - how did you find your BG's during the 2 week trial using the Oral Recosulin?  Did you have to use a basal insulin during the time period and only use the oral insulin for meals?  So many questions, and I'm excited to hear from someone who has had the chance to try it out (wish I'd been part of the test group!).  Glad to hear that there is no strange after taste, as that could put some people off (not myself, if it meant no more needles).

    Hoopster - thanks for the heads up on the approval for Oral-lyn here in Canada.  I'm going to see my endo in a few weeks (we've not seen each other since I went to the IDF Congress back in October).  I have lots of info to give to him that I had collected on diabetes (hope he has time set aside rather then his regular 20 minutes ).  I'll bring along the Oral-lyn "demo" that I have in the picture here - see what his expression is as I "inhale".

    Meanwhile, I've done abit of research at Health Canada for the SAP (Special Access Program) - and not having much luck finding what you've found.  If you've got the link, feel free to post it here if you want, so we "wanna be doctors" can look into it. 

    By: : Jan, 26, 2010 12:28 PM

    Anna, in case you are not aware. Health Canada has approved Ora-lyn under its Special Access Program.  To the best of my knowledge multiple patients with needle phobias and other problems that prevent their use of injectable insulin have taken advantage of this program.  I am in the US, so I assume you would need to get a prescription and/or request from your physician and submit it to Health Canada.

    Similarly, Ora-lyn has been approved in the US under the FDA's Investigational New Drug Program and approval is similarly granted.

    Good luck to you and please update us if you are successful in accessing Ora-lyn through the SAP.

    By: : Jan, 26, 2010 10:53 AM

    I had the opportunity to use Oral-Lyn (Oral Recosulin from India) for a few weeks and their is no objectional taste other than a slight aftertaste. It is not inhaled, but rather absorbed directly in the cheek mucosa. Should be a big hit when it finally comes to market in the US.

    By: spark: Nov, 23, 2009 10:57 AM

    Hmm.. personally, I would imagine it would be similar to how an inhaler (for asthmatics) tastes like.. I haven't personally tried or had the pleasure of smelling either, but I hardly ever find medicine to be pleasant in any way, shape, or form.. LOL

    Though maybe they'll have flavored versions of the Oral-Lyn like they do for the RapidSpray.. That coupled with the DS game for kids might really help motivate children to better manage their diabetes.. hehe

    By: FatCatAnna: Nov, 22, 2009 12:20 PM

    Generex Oral-lyn™Here's a picture we took this morning of my "using" the Oral-lyn™.  Remember, this is only the squeezy stress toy they gave to me - but still imagine not having to inject your insulin - but inhale it instead.  Tho' wonder what kind of taste would be left in your mouth?  Insulin smells wierd to begin with, have never actually dipped my finger into it, and tasted it (have you?). Ugh.

    insulin (1) spray (1) oral (1) sugar (1) blood (1) low (1)

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